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張雲菁 副教授

張雲菁 副教授

學  歷: 中山醫學大學博士

專  長: 醫學生化、食品營養、保健食品

電  話: 04-24730022轉12131

E-mail: changyc@csmu.edu.tw

Office Hour:每星期一 第七、八節

學歷

博士:中山醫學大學

經歷

2019/2~迄今 中山醫學大學 健康餐飲暨產業管理系 專任副教授
2012/2~迄今 中山醫學大學 生化暨生物科技研究所 副教授
2007/8~2012/7 中山醫學大學 生化暨生物科技研究所 助理教授
2006/8~2007/7 明道大學 休閒保健學系 專任助理教授

學術專長
醫學生化、食品營養、保健食品

研究著作
期刊論文

  1. Ching-Chuan Su, Chau-Jong Wang, Kai-Hsun Huang, Yi-Ju Lee, Wei-Ming Chan, Yun-Ching Chang,(2018), Anthocyanins from Hibiscus sabdariffa calyx attenuate in vitro and in vivo melanoma cancer metastasis. Journal of Functional Foods. 48, 614-631.
  2. Tsung-Chang Tsai, Hui-Pei Huang, Kai-Ting Chang, Chau-Jong Wang and Yun-Ching Chang. Anthocyanins from roselle extract arrest cell cycle G2/M phase transition via ATM/Chk pathway in p53-deficient leukemia HL-60 Cells. Environmental Toxicology, 1290-1304, 2016.
  3. Cheng-Hsun Wu, Chi-Chou Huang, Chia-Hung Hung, Fang-Yi Yao, Chau-Jong Wang, Yun-Ching Chang. Delphinidin-rich extracts of Hibiscus sabdariffa L. triggers mitochondria-derived autophagy and necrosis through reactive oxygen species in human breast cancer cells. Journal of Functional Foods, 25, 279-290, 2016.
  4. Chang YC, Yang MY, Chen SC, Wang CJ. Mulberry leaf polyphenol extract ameliorates obesity by inducing adipocyte apoptosis and inhibiting preadipocyte differentiation and hepatic lipogenesis. Journal of Functional Foods, 21, 249-262, 2016.
  5. Chang YC, Yang MY, Chen SC, Wang CJ. Mulberry leaf polyphenol extract ameliorates obesity by inducing adipocyte apoptosis and inhibiting preadipocyte differentiation and hepatic lipogenesis. Journal of Functional Foods, 21, 249-262, 2016. (SCI) (R/C=7/123,FOOD SCIENCE & TECHNOLOGY)
  6. Tsung-Chang Tsai, Hui-Pei Huang, Yun-Ching Chang*, Chau-Jong Wang. An anthocyanin-rich extract fromHibiscus Sabdariffa Linnaeus inhibits N-nitrosomethylurea-induced leukemia in rats. Journal of Agricultural and Food Chemistry, 62, 1572-1580, 2014. (SCI) *co-corresponding author.
  7. Cheng-Hsun Wu, Shu-Chun Chen, Ting-Tsz Ou, Charng-Cherng Chyau, Yun-Ching Chang*, Chau-Jong Wang. Mulberry leaf polyphenol extracts reduced hepatic lipid accumulation involving regulation of adenosine monophosphate activated protein kinase and lipogenic enzymes. Journal of Functional Foods, 5, 1620-1632, 2013. (SCI) *co-corresponding author.
  8. Jia-Jen Chang, Man-Jung Hsu, Hui-Pei Huang, Dai-Jung Chung, Yun-Ching Chang*, Chau-Jong Wang.Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance. Journal of Agricultural and Food Chemistry, 61, 6069-6076, 2013. (SCI) *co-corresponding author.
  9. Yun-Ching Chang, Jeng-Dong Hsu, Wea-Lung Lin, Yi-Ju Lee, Chau-Jong Wang. High incidence of acute promyelocytic leukemia a specifically induced by N-Nitroso-N-Methylurea (NMU) in Sprague-Dawley rats. Archives of Toxicology, 86, 315-327, 2012. (SCI)
  10. Mon-Yuan Yang, Yun-Ching Chang*, Kuei-Chuan Chan, Yi-Ju Le, Chau-Jong Wang. Flavonoid-enriched extracts from Nelumbo nucifera leaves inhibits proliferation of breast cancer in vitro and in vivo. European Journal of Integrative Medicine, 3, e153-e163, 2011. *co-first author.
  11. Hui-Pei Huang, Yun-Ching Chang*, Cheng-Hsun Wu, Chi-Nan Hung, Chau-Jong Wang. Anthocyanin-rich Mulberry extract inhibit the gastric cancer cell growth in vitro and xenograft mice by inducing signals of p38/p53 and c-jun. Food Chemistry, 129, 1703-1709, 2011. (SCI) *co-first author.
  12. Hsueh-Chun Wang, Dun-Hao Wu, Yun-Ching Chang, Yi-Ju Li, and Chau-Jong Wang. Solanum nigrum Linn. water extract inhibits metastasis in mouse melanoma cells in vitro and in vivo. Journal of Agricultural and Food Chemistry, 58, 11913-11923, 2010. (SCI)
  13. Hui-Pei Huang, Yuan-Wei Shih, Yun-Ching Chang, Chi-Nan Hung, Chau-Jong Wang. Chemoinhibitory effect of mulberry anthocyanins on melanoma metastasis involved in the Ras/PI3K pathway. Journal of Agricultural and Food Chemistry, 56, 9286-9293, 2008. (SCI)
  14. Yun-Ching Chang, Pinpin Lin. Trans, trans-2,4-decadienal induced cell proliferation via p27 pathway in human bronchial epithelial cells. Toxicology and Applied Pharmacology, 228, 76-83, 2008. (SCI)
  15. Louis W. Chang, Yun-Ching Chang, Chia-Chi Ho, Ming-Hsien Tsai and Pinpin Lin. Increase of carcinogenic risk via enhancement of cyclooxygenase-2 expression and hydroxyestradiol accumulation in human lung cells as a result of interaction between BaP and 17-beta estradiol. Carcinogenesis, 28, 1606-1612, 2007. (SCI)
  16. Yun-Ching Chang, Kai-Xun Huang, An-Chung Huang, Yung-Chyuan Ho and Chau-Jong Wang. Hibiscusanthocyanins-rich extract inhibited LDL oxidation and oxLDL-mediated macrophage apoptosis. Food and Chemical Toxicology, 44, 1015-1023, 2006. (SCI)
  17. Horng-Rong Chang, Jong-Da Lian, Chi-Hung Cheng, Chia-Wen Lo, Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang. Induction of urothelial proliferation in rats by aristolochic acid through cell cycle progression via activation of cyclin D1/cdk4 and cyclin E/cdk2. Food and Chemical Toxicology, 44, 28-35, 2006. (SCI)
  18. Wu-Hsien Kuo, Fen-Pi Chou, Shun-Chieh Young, Yun-Ching Chang and Chau-Jong Wang. Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes. Toxicology and Applied Pharmacology, 208, 155-162, 2005. (SCI)
  19. Yun-Ching Chang, Hui-Pei Huang, Jeng Dong Hsu, Shun-Fa Yang, Chau-Jong Wang. Hibiscus athocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. Toxicology and Applied Pharmacology, 205, 201-212, 2005. (SCI)
  20. Yun-Ching Chang, Fen-Pi Chou, Hui-Pei Huang, Jeng Dong Hsu, Chau-Jong Wang. Inhibition of cell cycle progression by penta-acetyl geniposide in rat C6 glioma cells. Toxicology and Applied Pharmacology, 198, 11-20, 2004. (SCI)
  21. Yun-Ching Chang, Tsui-Hwa Tseng, Miao-Jane Lee, Jeng Dong Hsu, Chau-Jong Wang. Induction of apoptosis by penta-acetyl geniposide in rat C6 glioma cells. Chemico-Biological Interactions, 141, 243-257, 2002. (SCI)
     


研討會論文

  1. Yu-Han Chiu, Chau-Jong Wang, Yun-Ching Chang. Effects of Sechium edule Shoot Extracts on Insulin Resistance in Rats with Type 2 Diabetes and Lipid Abnormalities. The 31th Joint Annual Conference of Biomedical Science (JACBS), Taipei, Taiwan R.O.C., 2016.
  2. Hui-Ting Lin, Chau-Jong Wang, Yun-Ching Chang. Hibiscus anthocyanins inhibit N-nitrosomethylurea-induced leukemia in rats. 2013 Annual Conference of International Society for Nutraceuticals and Functional Foods (ISNFF), Taipei, Taiwan R.O.C., 2013. (November 5-9)
  3. Wei-Ming Chen, Chau-Jong Wang, Yun-Ching Chang. Chemoinhibitory effect of Hibiscus anthocyanins extract on the metastasis in B16 melanoma cells. The 28th Joint Annual Conference of Biomedical Science (JACBS), Taipei, Taiwan R.O.C., 2013.
  4. Yun-Ching Chang, Kai-Xun Huang, Chau-Jong Wang. Hibiscus anthocyanins alleviate N-nitroso-N-methylurea (NMU)-induced leukemia in rats. The 71st Annual Meeting of the Japanese Cancer Association (JCA), Sapporo, Japan, 2012. (September 19Wed.- 21Fri)
  5. Wan-Ling Zeng, Chau-Jong Wang, Yun-Ching Chang. Anthocyanins: Evaluation of the in vivo and in vitro Antitumor Activity on Murine Leukemia. The 27th Joint Annual Conference of Biomedical Science (JACBS), Taipei, Taiwan R.O.C., 2012.
  6. Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang. Flavonoid-enriched extracts from Nelumbo nucifera leaves inhibits proliferation of breast cancer cells. The 5th International Conference on Food Factors (ICoFF), Taipei, Taiwan R.O.C., 2011. (November 20-23, 2011)
  7. Yun-Ching Chang, Mon-Yuan Yang, Chau-Jong Wang. Inhibitory effects of the water extract of Nelumbo Nucifera leaf on human breast carcinoma MCF-7 cells in vitro and in vivo. American Association for Cancer Research (AACR) 101st Annual Meeting 2010, Washington D.C., USA, 2010.
  8. Shu-Chun Chen, Yun-Ching Chang, Chau-Jong Wang. Mulberry Leave Polyphenols Reduced Lipid Accumulation in Hepatocytes The 24th Joint Annual Conference of Biomedical Science, Taipei, Taiwan R.O.C., 2009.
  9. Yun-Ching Chang, Yi-Ju Lee, Jeng-Dong Hsu, Chau-Jong Wang. Antitumor effect of Hibiscus anthocyanisns rich extract. The 5th Annual Conference of Health Food Society, Taipei, Taiwan R.O.C., 2007.
  10. Pinpin Lin, Wei-Sze Lo, Yun-Ching Chang and Louis W. Chang. Increased cell proliferation and reduced p27 expression by trans, trans-2,4-decadienal via oxidative stress in human bronchial epithelial cells. The 45th Society of Toxicology (SOT) Annual Meeting, San Diego, California, USA, 2006.
  11. Pinpin Lin, Louis W. Chang, Yun-Ching Chang and Chia-Chi Ho. Toxicogenomic and proteomic studies on cooking oil fumes, an environmental risk factor, in association with female lung adenocarcinoma. The 7th Symposium of National Research Program for Genomic Medicine (NRPGM), Taipei, Taiwan R.O.C., 2006.
  12. Yun-Ching Chang, Hui-Hsuan Lin and Chau-Jong Wang. Antitumor effect of Hibiscus anthocyanins and polyphenol rich extract in vitro and in vivo. The 20th Joint Annual Conference of Biomedical Science, Taipei, Taiwan R.O.C., 2005.
  13. Yun-Ching Chang and Chau-Jong Wang. Inhibition of cell cycle progression by penta-acetyl geniposide in rat C6 glioma cells. The 16th Joint Annual Conference of Biomedical Science, Taipei, Taiwan R.O.C., 2001.